![]() De Bacquer et al 2 found major morphological ECG changes in 5.5 per cent of 47358 working individuals between 40 and 64 yr of age using data derived from four large epidemiological studies performed in Belgium over a 30 year period. In 1962, Hiss and Lamb published data on 122,043 healthy male air force pilots aged 16 to 50 yr they found that 5,773 subjects (4.72%) had electrocardiographic abnormalities 1. Morphological abnormalities in the 12-lead electrocardiogram (ECG) may occur in healthy individuals. Further studies are required to determine whether these abnormalities persist or if some of these disappear on follow up. Morphological abnormalities in ECG are commonly seen in healthy volunteers participating in phase I studies and vary with age and gender. ![]() Prolonged PR interval, RBBB and intraventricular conduction defects were more common in males while sinus tachycardia, short PR interval and non-specific T wave changes were more frequent in females. Morphological abnormalities were detected in 25.5 per cent of 3978 healthy volunteers (2495 males, 1483 females aged 18-76 yr) the presence was higher in males (29.3% vs. ECG intervals were measured on five consecutive beats and morphological abnormalities identified using standard guidelines. A single drug-free baseline ECG from each subject was reviewed by experienced cardiologists. Methods:ĮCGs from 62 phase I studies analyzed in a central ECG laboratory were pooled. As these populations may not truly represent healthy individuals, we assessed morphological abnormalities in ECG in healthy volunteers participating in phase I studies, who are screened to exclude associated conditions. Morphological abnormalities in 12-lead electrocardiograms (ECGs) are seen in subgroups of healthy individuals like athletes and air-force personnel.
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